Protein translocation through a small pore is a ubiquitous process in molecular biology. An artificial or a biological nanopore can in principle sequence protein and provide information about the secondary and tertiary structures from the current blockade characteristics of the translocating protein through the pore. We will study this phenomenon using a model protein and a pore. The molecular dynamics simulation studies will provide information about transient folding and unfolding processes as different amino acids pass through the pore. Students will be running simulation, analyze and visualize data using the code that will be provided. Some knowledge of Python will be a plus, although not necessary. They will be encouraged to present the research results during the showcase of undergraduate research and at the APS meetings.
Project Dates
Start Date: 1/6/2024 - End Date: 5/31/2025
Students Needed
Type of Project
Individual
Student Responsibilities
Students need to learn how to use a few well-established simulation platforms, participate in weekly meetings and work with a long-term goal to present their results at UCF and other national and international meetings.
Time Commitment
4-5 hours per week hour(s)
Student Requirements
Student must register for a zero-credit research.
Interested in Working With the Following Programs
For EXCEL URE Students Only
Additional Notes
Students need to learn how to use a few well-established simulation platforms, participate in weekly meetings and work with a long-term goal to present their results at UCF and other national and international meetings.