Get to know Andrew’s research: Mycobacterium tuberculosis (Mtb), the causative agent behind tuberculosis, remains a significant global health issue, holding the position as the deadliest single-agent infection worldwide. This work focused on developing efficient methods for synthesizing nitramines to evaluate their potential as inhibitors of ICL1. Our findings suggest a promising route of nitramine synthesis, allowing their investigation as inhibitors that have suggested they function differently than their nitroalkane counterparts in regard to ICL1 interaction.

Andrew’s advice: “The key to success in research is found in consistency. It’s easy to become discouraged by failed experiments or unexpected results, especially with research projects. However, those setbacks are a normal and necessary part of the journey. Rather than viewing mistakes as failures, treat them as a unique result of their own: an opportunity to reflect on your approach and gain a more comprehensive understanding. Progress in research is rarely linear, so staying persistent, even when results are unexpected or undesirable, is what will eventually lead to meaningful outcomes.”