Single molecule protein sequencing through a nanopore is a modern method to understand physical properties of a protein – one of the major building blocks of life. Proteome analysis is a key to understand various biological processes. The project involves modeling and simulation studies of translocation of a few intrinsically disordered proteins (identified to be responsible of diseases) through biological and synthetic nanopores. The translocation will reveal dominant intra-chain interaction which will help to understand the global conformations and dynamics of these proteins and factors affecting their aggregation. Students will be running simulation, analyze and visualize data using the code that will be provided. Some knowledge of Python will be a plus, although not necessary. They will be encouraged to present the research results during UCF showcase of undergraduate research and/or at the APS meetings.
Project Dates
Start Date: 10/2/2023 - End Date: 5/31/2024
Students Needed
Type of Project
Individual
Student Responsibilities
Students need to learn how to use a few standard molecular dynamics simulation softwares, run codes, analyze data, make ppt presentation and attend weekly meeting. They should have a goal to make research presentation at UCF showcase of UG research and at the APS meetings.
Time Commitment
4-5 hours per week hour(s)
Student Requirements
should register for zero research credit
Interested in Working With the Following Programs
Honors Undergraduate Thesis
Independent Research Credit (4912)
McNair Scholars
Research and Mentoring Program
Summer Undergraduate Research Fellowship
Additional Notes
Interested students should seek stipend opportunities through UCFs' several programs RAMP/EXCEL/COMPASS etc.