Undergraduate Research

My research project involved investigating the effects of linearized neurons on mRNA localization patterns. mRNA localization is a fundamental cellular process whereby messenger RNA (mRNA) molecules are selectively transported and positioned within cells, facilitating specific protein synthesis and cellular functions. Previous studies had explored dendritic mRNA localization patterns in mouse neurons using standard neuron growth culture methods. However, the visualization of mRNA localization with this approach lacked the precision required for detailed examination of dendritically-based RNA. To address this limitation and gain deeper insights, we investigated the impact of culturing neurons in a linearized pattern on mRNA localization patterns. Our results demonstrated that cultivating neurons in a linear orientation allowed us to achieve high-resolution capture of Shank1 localization within the dendrites of linear neurons. 

Arlette’s advice? Embrace a growth mindset! “When you encounter an opportunity that resonates with your goals and aspirations, it’s imperative to approach it with unwavering commitment. Seek support from mentors and peers who can provide valuable insight and validation. Break your objectives into manageable, incremental steps, and track your accomplishments. Embrace the philosophy of a growth mindset, understanding that competence can be cultivated through learning and perseverance. You CAN do it…I believe in you!”